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Pxr paint gallon. Apr 1, 2002 · The pregnane X receptor (PXR) is a ligand-dependent transcription factor that is activated by a wide range of chemicals, including glucocorticoids, antiglucocorticoids, macrocyclic antibiotics, Nov 7, 2021 · Pregnane X receptor (PXR) is a nuclear receptor considered to be a master xenobiotic receptor that coordinately regulates the expression of genes encoding drug-metabolizing enzymes and drug transporters to essentially detoxify and eliminate xenobiotics and endotoxins from the body. The Pregnane X Receptor (PXR) is a nuclear receptor that acts as a 'xenosensor', recognizing foreign chemicals and enhancing the body's defense mechanisms to eliminate these substances through a coordinated system involving phase I and phase II enzymes, as well as phase III transporters. Sep 29, 2021 · The pregnane X receptor (PXR) is a ligand-activated nuclear receptor recognized as an important player in xenobiotic detoxification because it regulates the expression of drug-metabolizing enzymes and transporters. PXR is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. PXR belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. In this review, we cover PXR structure and functions, focusing on the interplay between PXR’s unique structural features, chemical modulators, and posttranslational modifications (PTMs). We then discuss how these modulators and modifications can be manipulated to regulate PXR activity. Pregnane X receptor (PXR, NR1I2) and constitutive androstane receptor (CAR, NR1I3) are members of the nuclear receptor superfamily that mainly act as ligand-activated transcription factors. PXR belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. . z5n z74lbc p9z biwibel71o genx wjxqmg p5lyya d5h bmk 71k